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Monday, July 27, 2020 | History

2 edition of Studies of bacteriophage active against the mycobacteria. found in the catalog.

Studies of bacteriophage active against the mycobacteria.

Paul M. Tracey

Studies of bacteriophage active against the mycobacteria.

by Paul M. Tracey

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  • 3 Currently reading

Published .
Written in English


Edition Notes

Thesis (M.A.) -- University of Toronto, 1954.

The Physical Object
Pagination1 v.
ID Numbers
Open LibraryOL18915467M

because it is active against both prokaryotic and eukaryotic cells. Why do antimicrobial agents active against mycobacteria have to be administered for months or years rather than the typical days prescribed to treat other infections? The process of acquiring antibiotic resistance by means of bacteriophage activity is called. Why do antimicrobial agents active against mycobacteria have to be administered for months or years rather than the typical days prescribed to treat other infections? a. Mycobacteria do not have cell walls. b. The only available agents are relatively ineffective drugs. c. They are too toxic to be used on a more rapid administration.

  Figure legend: Bacteriophage T4 as a computer-generated image, generated by the master of phage graphics himself, Steven McQuinn. The primary phage task is the infection of bacteria, production of new phages, and the release of those phages from the infected bacterium. Mycobacteriophages are viruses that infect the mycobacteria Historically, they have been used to overcome major road blocks in the genetic manipulation of mycobacteria. Mycobacteriophages have been used to demonstrate mycobacterlal transfection (1) and transduction (2).

  Background. Buruli Ulcer (BU) is a neglected, necrotizing skin disease caused by Mycobacterium tly, there is no vaccine against M. ulcerans infection. Although the World Health Organization recommends a combination of rifampicin and streptomycin for the treatment of BU, clinical management of advanced stages is still based on the surgical resection of infected skin.   A year-old patient with cystic fibrosis with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic.


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Studies of bacteriophage active against the mycobacteria by Paul M. Tracey Download PDF EPUB FB2

Phage therapy. The increasing emergence of infection, coinfection, and drug-resistant pathogens has become a severe challenge for scientists and public health.8,9 In recent years, several novel alternative strategies including therapeutic enzymes, pigments, phytochemicals, antimicrobial polymers, antimicrobial peptides, and silver nanoparticles have led researchers to consider the Cited by: 3.

More than forty bacteriophages lytic for saprophytic mycobacterial strains have been isolated from soil. Seven were isolated without enrichment, one following enrichment with ATCC No. and Mycobacterium phlei, and the remainder following enrichment with ATCC No. ment with ATCC No.

followed by resulted in isolation of a phage which lysed specifically the by: 6. Discovery. A bacteriophage found to infect Mycobacterium smegmatis in was the first documented example of a mycobacteriophage. It was found in cultures of the bacteria originally growing in moist compost.

The first bacteriophage that infects M. tuberculosis was discovered in Diversity. Thousands of mycobacteriophage have been isolated using a single host strain, Mycobacterium.

More than forty bacteriophages lytic for saprophytic mycobacterial strains have been isolated from soil. Seven were isolated without enrichment, one following enrichment with ATCC No.

and Myco-bacterium phlei, and the remainder following enrichment with ATCC No. only. Enrichment with ATCC No. followed by M. phlei resulted in isolation of a phage which lysed specifically the M. phlei Cited by: 6. TAKEYA K, YOSHIMURA T.

Isolation of bacteriophage active against all types of Mycobacterium tuberculosis. J Bacteriol. Oct; 74 (4)– [PMC free article] TAKEYA K, YOSHIMURA T, YAMAURA K, TODA T. Studies on the biologic properties of mycobacteriophage. Am Rev Respir Dis. Oct; –Author: M. Zykov, Ju. Donec, B.

Godovannyi. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (M), or click on a page image below to browse page by page.

Links to PubMed are also available for Selected References. The application of bacteriophages for biocontrol has attracted increasing attention. Here, we applied ϕBTCU-1 as a model phage to develop a method for controlling Mycobacterium tuberculosis (MTB) by using a bacteriophage-containing aerosol in a chamber study.

The soil-isolated ϕBTCU-1 can infect both MTB and Mycobacterium smegmatis. Our study used M. smegmatis as an MTB surrogate for.

Corpus ID: A Comparative Study of Three Mycobacteriophages @inproceedings{KraissACS, title={A Comparative Study of Three Mycobacteriophages}, author={James P. Kraiss}, year={} }. Methods are outlined by which phages active against mycobacteria were isolated from soil cultures enriched periodically with certain unspecified acidfast saprophytes.

Out of 26 phages studied, 4 showed some activity against virulent strains of human and bovine tubercle bacillus as well as against an assortment of saprophytes.

When the 4 phages were tested against strains of tubercle. mycobacteria transition from environmental bacteria to clinical pathogens, or what genetic elements influence the differences in virulence among strains of the same species. A potential mechanism of genetic evolution and diversity within mycobacteria is the presence of integrated viruses called prophages in the host genome.

One hundred strains of Mycobacterium tuberculosis isolated from cases of pulmonary tuberculosis in Nepalese villagers were typed with the World Health Organization set of bacteriophages.

The number of strains in the 3 major phage types A, I, and B w 53, and 28 respectively. This distribution is significantly different from those described in other geographical regions. Bacteriophage, any of a group of viruses that infect bacteria.

Bacteriophages were discovered independently by Frederick W. Twort in Great Britain () and Felix d’Herelle in France ().

Thousands of varieties of phages exist. Certain types serve key roles in laboratory research. Why do antimicrobial agents active against mycobacteria have to be administered for months or years rather than the typical days prescribed to treat other infections. The process of acquiring antibiotic resistance by means of bacteriophage activity is called peds Exam 2 Study guide book questions ch.

70 terms. Effect of TM4 phage on Mycobacterium avium and Mycobacterium tuberculosis viability.M. avium and M. tuberculosis were incubated with TM4 for 1 h, and then the no. of viable bacteria was determined over time.

There was a rapid killing of M. avium following exposure to the phage (P. Thus, studies of microbial physiology, structure, genetics and diagnostic tools have mainly focused on M. tuberculosis and secondarily on Mycobacterium leprae. The genus Mycobacterium is the only genus in the family of the Mycobacteriaceae 6 and is related to other mycolic acid-containing genera.

All mycobacteria are aerobic (though some. The electron-dense bodies of Mycobacterium phlei. J Gen Microbiol. Oct; 13 (2)– SELLERS MI, TOKUYASU K, PRICE Z, FROMAN S.

Electron microscopic studies of mycobacteriophages. Am Rev Tuberc. Dec; 76 (6)– TAKEYA K, YOSHIMURA T. Isolation of bacteriophage active against all types of Mycobacterium tuberculosis. Bacteriophages are being considered as a promising natural resource for the development of alternative strategies against mycobacterial diseases, especially in the context of the wide-spread occurrence of drug resistance among the clinical isolates of Mycobacterium r, there is not much information documented on mycobacteriophages from India.

Raman Verma, Benjamin M C Swift, Wade Handley-Hartill, Joanne K Lee, Gerrit Woltmann, Catherine E D Rees, Pranabashis Haldar, A Novel, High-sensitivity, Bacteriophage-based Assay Identifies Low-level Mycobacterium tuberculosis Bacteremia in Immunocompetent Patients With Active and Incipient Tuberculosis, Clinical Infectious Diseases, Volume Mycobacterium is a genus of Actinobacteria, given its own family, the species are recognized in this genus.

This genus includes pathogens known to cause serious diseases in mammals, including tuberculosis (Mycobacterium tuberculosis) and leprosy (Mycobacterium leprae) in humans. The Greek prefix myco-means "fungus," alluding to the way mycobacteria have been.

Ann. Virol. (Inst. Pasteur)E, ADSORPTION AND GROWTH OF THE BACTERIOPHAGE D29 IN SELECTED MYCOBACTERIA by H. David, S. Clavel and F. Clement Service de la Tuberculose el des,Vlycobacties, Instilul Fasleur, Paris Cedex 15 RUM ADSORPTION ET CROISSANCE DU BACTIOPHAGE Dz.

Chromatin staining of bacteria during bacteriophage infection. J Bacteriol. Apr; 59 (4)– [PMC free article] Mudd S. CELLULAR ORGANIZATION IN RELATION TO FUNCTION. Bacteriol Rev. Dec; 20 (4)– [PMC free article] HENDERSON HJ, MUDD S, TAKEYA K.

Electron-scattering granules and reducing sites in mycobacteria.Nontuberculous mycobacterial (NTM) infections are increasing in prevalence, with current estimates suggesting that overpeople in the United States are affected each year. It is unclear how certain species of mycobacteria transition from environmental bacteria to clinical pathogens, or what genetic elements influence the differences in virulence among strains of the same species.

A.Explore the latest full-text research PDFs, articles, conference papers, preprints and more on ENDOLYSIN. Find methods information, sources, references or conduct a .